Article
A novel common single nucleotide polymorphism in the promoter region of the C-reactive protein gene associated with the plasma concentration of C-reactive protein.
Atherosclerosis - 1 Jan 2005
Kovacs Alexander, Green Fiona, Hansson Lars-Olof, Lundman Pia, Samnegård Ann, Boquist Susanna, Ericsson Carl-Göran, Watkins Hugh, Hamsten Anders, Tornvall Per
Abstract excerpt
The plasma CRP concentration has consistently been shown to be associated with the risk of future coronary heart disease (CHD) and recent studies have suggested that CRP has a pathogenic role in CHD. Family studies and genotype-phenotype association studies of known polymorphisms in the intron, second exon and 3'-untranslated region (UTR) have suggested that plasma CRP concentrations are under genetic control....
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