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Article

Monogenic forms of insulin resistance: apertures that expose the common metabolic syndrome.

Trends in endocrinology and metabolism: TEM - 1 Oct 2003

Hegele Robert A

Abstract excerpt

Insulin resistance is common and plays a central role in the pathogenesis of type 2 diabetes mellitus (T2DM). Precedents in biomedical research indicate that evaluation of monogenic syndromes can help to understand a common complex phenotype. Monogenic forms of insulin resistance, such as familial partial lipodystrophy, which results from mutations in either LMNA (encoding lamin A/C) or PPARG (encoding peroxisome...

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Source

Identifiers

PMID: 14516935
DOI: 10.1016/s1043-2760(03)00142-5

Genes

AGPAT2
BSCL2
LMNA
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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