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Article

Role of DNA repair systems in malignant tumor development in the elderly.

Geriatrics & gerontology international - 1 Jun 2008

Arai Tomio, Sawabe Motoji, Hosoi Takayuki, Tanaka Noriko

Abstract excerpt

The increased incidence of malignant neoplasms in the elderly is related to the accumulation of damaged DNA. We focused on the molecular mechanisms of the DNA repair system and examined its relationship to malignant neoplasms in the elderly. Hypermethylation of the promoter region of a mismatch repair gene is strongly associated with gastric and colorectal carcinomas occurring in the elderly. These tumors have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18713157
DOI: 10.1111/j.1447-0594.2008.00450.x

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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