Article
Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer.
Histology and histopathology - 1 Jan 2002
Tamura G
Abstract excerpt
Both genetic and epigenetic alterations of tumor suppressor and tumor-related genes involved in the pathogenesis of gastric cancer are reviewed here, and molecular pathways of gastric carcinogenesis are proposed. Gastric carcinomas are believed to evolve from native gastric mucosa or intestinal metaplastic mucosa that undergoes genetic and epigenetic alterations involving either the suppressor pathway (defects in...
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