Article
Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancer
3 Mar 2011
Abstract excerpt
CDH1, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in carcinomas, we investigated the methylation status of the CDH1 gene 5'-CpG islands and its regulatory...
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