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Mitochondrial DNA haplogroups do not influence the Huntington's disease phenotype.

Neuroscience letters - 17 Oct 2008

Mancuso Michelangelo, Kiferle Lorenzo, Petrozzi Lucia, Nesti Claudia, Rocchi Anna, Ceravolo Roberto, Orsucci Daniele, Maluccio Maria Rosaria, Bonuccelli Ubaldo, Filosto Massimiliano, Siciliano Gabriele, Murri Luigi

Abstract excerpt

Various lines of evidence demonstrate the involvement of mitochondrial dysfunction in the pathogenesis of Huntington's disease (HD). However, the precise role of mitochondria in the neurodegenerative cascade leading to HD is still unclear. Mitochondrial DNA (mtDNA) haplogroups-specific polymorphisms were previously related to several neurodegenerative diseases. The length of CAG repeat seems to be related to the...

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PMID: 18706972
DOI: 10.1016/j.neulet.2008.08.013

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