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Article

Decomposing the energetic impact of drug-resistant mutations: the example of HIV-1 protease-DRV binding.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2012

Cai Yufeng, Schiffer Celia

Abstract excerpt

HIV-1 protease is a major drug target for AIDS therapy. With the appearance of drug-resistant HIV-1 protease variants, understanding the mechanism of drug resistance becomes critical for rational drug design. Computational methods can provide more details about inhibitor-protease binding than crystallography and isothermal titration calorimetry. The latest FDA-approved HIV-1 protease inhibitor is Darunavir (DRV)....

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Identifiers

PMID: 22183557
DOI: 10.1007/978-1-61779-465-0_32
PMCID: PMC4868624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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