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Article

Vitamin D3 induces pro-LL-37 expression in myeloid precursors from patients with severe congenital neutropenia

14 Aug 2008

Abstract excerpt

The innate immune system produces a number of effector molecules that are important for protection against bacterial infections. Neutrophils and antimicrobial peptides are major components of innate defense with the capacity of rapid bacterial killing. Patients with severe congenital neutropenia (SCN) experience recurrent and chronic infections despite recombinant G-CSF-mobilized neutrophils. We have shown...

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PMID: 18703682
DOI: 10.1189/jlb.0607437

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