Article
Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis.
PloS one - 13 Aug 2008
Cohen Clemens D, Lindenmeyer Maja T, Eichinger Felix, Hahn Alexander, Seifert Martin, Moll Anton G, Schmid Holger, Kiss Eva, Gröne Elisabeth, Gröne Hermann-Josef, Kretzler Matthias, Werner Thomas, Nelson Peter J
Abstract excerpt
BACKGROUND: Diabetic nephropathy (DN) is a complex and chronic metabolic disease that evolves into a progressive fibrosing renal disorder. Effective transcriptomic profiling of slowly evolving disease processes such as DN can be problematic. The changes that occur are often subtle and can escape detection by conventional oligonucleotide DNA array analyses. METHODOLOGY/PRINCIPAL FINDINGS: We examined...
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