Article
Defining human diabetic nephropathy on the molecular level: integration of transcriptomic profiles with biological knowledge.
Reviews in endocrine & metabolic disorders - 1 Dec 2008
Martini Sebastian, Eichinger Felix, Nair Viji, Kretzler Matthias
Abstract excerpt
Diabetic nephropathy (DN) is the most common cause for end stage renal disease (ESRD). Next to environmental factors, genetic predispositions determine the susceptibility for DN and its rate of progression to ESRD. With the availability of genome wide expression profiling we have the opportunity to define relevant pathways activated in the individual diabetic patient, integrating both environmental exposure and...
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