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Article

Btn1 affects cytokinesis and cell-wall deposition by independent mechanisms, one of which is linked to dysregulation of vacuole pH.

Journal of cell science - 1 Sept 2008

Codlin Sandra, Haines Rebecca L, Burden J Jemima E, Mole Sara E

Abstract excerpt

btn1, the Schizosaccharomyces pombe orthologue of the human Batten-disease gene CLN3, is involved in vacuole pH homeostasis. We show that loss of btn1 also results in a defective cell wall marked by sensitivity to zymolyase, a beta-glucanase. The defect can be rescued by expression of Btn1p or CLN3, and the extent of the defect correlates with disease severity. The vacuole and cell-wall defects are linked by a...

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Source

Identifiers

PMID: 18697832
DOI: 10.1242/jcs.030122

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Btn1 affects cytokinesis and cell-wall deposition by independent mechanisms, one of which is linked to dysregulation of vacuole pH.PMID 18697832Read ↗

btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.Semantic proximity Read ↗

The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis.Semantic proximity Read ↗

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The fission yeast model for the lysosomal storage disorder Batten disease predicts disease severity caused by mutations in CLN3.Semantic proximity Read ↗

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