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Article

Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.

Nature genetics - 1 May 1999

Pearce D A, Ferea T, Nosel S A, Das B, Sherman F

Abstract excerpt

Neuronal ceroid-lipofuscinoses (NCL) are autosomal recessive disorders that form the most common group of progressive neurodegenerative diseases in children, with an incidence as high as 1 in 12,500 live births, and with approximately 440,000 carriers in the United States. Disease progression is...

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Source

Identifiers

PMID: 10319861
DOI: 10.1038/8861

Genes

CLN3
NCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10319861-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.PMID 10319861Read ↗

The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis.Semantic proximity Read ↗

Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p.Semantic proximity Read ↗

Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease.Semantic proximity Read ↗

btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.Semantic proximity Read ↗

Investigation of Batten disease with the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Interaction between Sdo1p and Btn1p in the Saccharomyces cerevisiae model for Batten disease.Semantic proximity Read ↗

The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p.Semantic proximity Read ↗

The fission yeast model for the lysosomal storage disorder Batten disease predicts disease severity caused by mutations in CLN3.Semantic proximity Read ↗

Current Insights in Elucidation of Possible Molecular Mechanisms of the Juvenile Form of Batten Disease.Semantic proximity Read ↗

Nitric oxide signaling is disrupted in the yeast model for Batten disease.Semantic proximity Read ↗

Characterizing pathogenic processes in Batten disease: use of small eukaryotic model systems.Semantic proximity Read ↗

Btn1 affects cytokinesis and cell-wall deposition by independent mechanisms, one of which is linked to dysregulation of vacuole pH.Semantic proximity Read ↗

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