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Article

The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis.

Journal of bacteriology - 1 Nov 2000

Chattopadhyay S, Muzaffar N E, Sherman F, Pearce D A

Abstract excerpt

The BTN1 gene product of the yeast Saccharomyces cerevisiae is 39% identical and 59% similar to human CLN3, which is associated with the neurodegenerative disorder Batten disease. Furthermore, btn1-Delta strains have an elevated activity of the plasma membrane H(+)-ATPase due to an abnormally hig...

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Identifiers

PMID: 11053386
DOI: 10.1128/JB.182.22.6418-6423.2000
PMCID: PMC94788

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11053386-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis.PMID 11053386Read ↗

Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.Semantic proximity Read ↗

Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease.Semantic proximity Read ↗

Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p.Semantic proximity Read ↗

The yeast model for Batten disease: a role for Btn2p in the trafficking of the Golgi-associated vesicular targeting protein, Yif1p.Semantic proximity Read ↗

Btn1 affects cytokinesis and cell-wall deposition by independent mechanisms, one of which is linked to dysregulation of vacuole pH.Semantic proximity Read ↗

btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.Semantic proximity Read ↗

Interaction between Sdo1p and Btn1p in the Saccharomyces cerevisiae model for Batten disease.Semantic proximity Read ↗

Investigation of Batten disease with the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae.Semantic proximity Read ↗

The fission yeast model for the lysosomal storage disorder Batten disease predicts disease severity caused by mutations in CLN3.Semantic proximity Read ↗

The yeast endosomal Na+K+/H+ exchanger Nhx1 regulates cellular pH to control vesicle trafficking.Semantic proximity Read ↗

Btn2, a Hook1 ortholog and potential Batten disease-related protein, mediates late endosome-Golgi protein sorting in yeast.Semantic proximity Read ↗

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