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Article

Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 1999

Pearce D A, Carr C J, Das B, Sherman F

Abstract excerpt

BTN1 of Saccharomyces cerevisiae encodes an ortholog of CLN3, the human Batten disease gene. We have reported previously that deletion of BTN1, btn1-Delta, resulted in a pH-dependent resistance to D-(-)-threo-2-amino-1-[p-nitrophenyl]-1,3-propanediol (ANP). This phenotype was caused by btn1-Delta strains having an elevated ability to acidify growth medium through an elevated activity of the plasma membrane...

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Source

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Identifiers

PMID: 10500178
DOI: 10.1073/pnas.96.20.11341
PMCID: PMC18035

Genes

CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease.PMID 10500178Read ↗

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btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.Semantic proximity Read ↗

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