Article
Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting.
Traffic (Copenhagen, Denmark) - 1 Sept 2004
Shiflett Shelly L, Vaughn Michael B, Huynh Dinh, Kaplan Jerry, Ward Diane McVey
Abstract excerpt
Mutations in the Chediak-Higashi syndrome gene (CHS1) and its murine homologue Beige result in the formation of enlarged lysosomes. BPH1 (Beige Protein Homologue 1) encodes the Saccharomyces cerevisiae homologue of CHS1/Beige. BPH1 is not essential and the encoded protein was found to be both cytosolic and peripherally bound to a membrane. Neither disruption nor overexpression of BPH1 affected vacuole morphology...
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