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Article

Rifampicin reduces α-synuclein in a transgenic mouse model of multiple system atrophy

27 Aug 2008

Abstract excerpt

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by oligodendrocytic cytoplasmic inclusions containing abnormally aggregated alpha-synuclein. This aggregation has been linked to the neurodegeneration observed in MSA. Current MSA treatments are aimed at controlling symptoms rather than tackling the underlying cause of neurodegeneration. This study investigates the ability of...

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PMID: 18695506
DOI: 10.1097/wnr.0b013e32830b3661

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