Article
Disease-specific induced pluripotent stem cells.
Cell - 5 Sept 2008
Park In-Hyun, Arora Natasha, Huo Hongguang, Maherali Nimet, Ahfeldt Tim, Shimamura Akiko, Lensch M William, Cowan Chad, Hochedlinger Konrad, Daley George Q
Abstract excerpt
Tissue culture of immortal cell strains from diseased patients is an invaluable resource for medical research but is largely limited to tumor cell lines or transformed derivatives of native tissues. Here we describe the generation of induced pluripotent stem (iPS) cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance; these diseases include adenosine deaminase...
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