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Article

Role of positively charged amino acids in the M2D transmembrane helix of Ktr/Trk/HKT type cation transporters.

Channels (Austin, Tex.) - 1 Jan 2000

Kato Naoki, Akai Masaro, Zulkifli Lalu, Matsuda Nobuyuki, Kato Yasuhiro, Goshima Shinobu, Hazama Akihiro, Yamagami Mutsumi, Guy H Robert, Uozumi Nobuyuki

Abstract excerpt

Studies suggest that Ktr/Trk/HKT-type transporters have evolved from multiple gene fusions of simple K(+) channels of the KcsA type into proteins that span the membrane at least eight times. Several positively charged residues are present in the eighth transmembrane segment, M2(D), in the transporters but not K(+) channels. Some models of ion transporters require a barrier to prevent free diffusion of ions down...

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PMID: 18690031
DOI: 10.4161/chan.4374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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