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Article

The role of the polycomb complex in silencing α-globin gene expression in nonerythroid cells

8 Aug 2008

Abstract excerpt

Although much is known about globin gene activation in erythroid cells, relatively little is known about how these genes are silenced in nonerythroid tissues. Here we show that the human alpha- and beta-globin genes are silenced by fundamentally different mechanisms. The alpha-genes, which are surrounded by widely expressed genes in a gene dense region of the genome, are silenced very early in development via...

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PMID: 18689541
DOI: 10.1182/blood-2008-06-161901

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