Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ohno's dilemma: evolution of new genes under continuous selection.

Proceedings of the National Academy of Sciences of the United States of America - 23 Oct 2007

Bergthorsson Ulfar, Andersson Dan I, Roth John R

Abstract excerpt

New genes with novel functions arise by duplication and divergence, but the process poses a problem. After duplication, an extra gene copy must rise to sufficiently high frequency in the population and remain free of common inactivating lesions long enough to acquire the rare mutations that provide a new selectable function. Maintaining a duplicated gene by selection for the original function would restrict the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Gene Transfer, Horizontal

Share to Models, Genetic

Share to Point Mutation

Share to Recombination, Genetic

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 17942681
DOI: 10.1073/pnas.0707158104
PMCID: PMC2040452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ohno's dilemma: evolution of new genes under continuous selection.PMID 17942681Read ↗

Real-time evolution of new genes by innovation, amplification, and divergence.Semantic proximity Read ↗

Ohno's model revisited: measuring the frequency of potentially adaptive mutations under various mutational drifts.Semantic proximity Read ↗

Intrinsically driven changes in gene interaction complexity. I. Growth of regulatory complexes and increase in number of genes.Semantic proximity Read ↗

Simulating evolution of protein complexes through gene duplication and co-option.Semantic proximity Read ↗

Turning a hobby into a job: how duplicated genes find new functions.Semantic proximity Read ↗

Invasion and maintenance of a gene duplication.Semantic proximity Read ↗

New gene evolution: little did we know.Semantic proximity Read ↗

Information theory, evolutionary innovations and evolvability.Semantic proximity Read ↗

Neutral and nonneutral mutations: the creative mix--evolution of complexity in gene interaction systems.Semantic proximity Read ↗

Early effects of gene duplication on the robustness and phenotypic variability of gene regulatory networks.Semantic proximity Read ↗

Multiple routes to subfunctionalization and gene duplicate specialization.Semantic proximity Read ↗

A Synergistic, Cultivator Model of De Novo Gene Origination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.