Article
Phenotypic and genotypic characterization of drug-resistant Mycobacterium tuberculosis strains.
Diagnostic microbiology and infectious disease - 1 Oct 2008
Clemente Wanessa Trindade, Soares Lima Stella Sala, Palaci Moises, Silva Márcia S N, Sumnienski Rodrigues Vivian F, Dalla Costa Elis R, Possuelo Lia, Cafrune Patrícia Izquierdo, Ribeiro Fabíola Karla, Gomes Harisson M, Serufo José Carlos
Abstract excerpt
Of 142 pulmonary tuberculosis patients, 76 were considered high risk for the development of resistance, and 24 were confirmed as resistant strain carriers. Resistant isoniazid strains presented a high frequency of katG and ahpC mutations (90%) correlated with an MIC >4 microg/mL (94%). inhA mutations were not seen. rpoB mutations were identified in 78.6% of rifampicin-resistant strains, usually in codon 531...
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