Article
NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.
BMC bioinformatics - 5 Aug 2008
Nowak Robert M, Płoski Rafał
Abstract excerpt
BACKGROUND: Laboratory techniques used to determine haplotypes are often too expensive for large-scale studies and lack of phase information is commonly overcome using likelihood-based calculations. Whereas a number of programs are available for that purpose, none of them can handle loci with both multiple and null alleles. RESULTS: Here we present a description of a modified Expectation - Maximization algorithm...
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