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The dark side of BrdU in neural stem cell biology: detrimental effects on cell cycle, differentiation and survival.

Cell and tissue research - 1 Sept 2011

Lehner Bernadette, Sandner Beatrice, Marschallinger Julia, Lehner Christine, Furtner Tanja, Couillard-Despres Sebastien, Rivera Francisco J, Brockhoff Gero, Bauer Hans-Christian, Weidner Norbert, Aigner Ludwig

Abstract excerpt

5-Bromo-2'-deoxyuridin (BrdU) is frequently used in anaylsis of neural stem cell biology, in particular to label and to fate-map dividing cells. However, up to now, only a few studies have addressed the question as to whether BrdU labeling per se affects the cells to be investigated. Here, we focused on the potential impact of BrdU on neurosphere cultures derived from the adult rat brain and on proliferation of...

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PMID: 21837406
DOI: 10.1007/s00441-011-1213-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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