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Article

Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer.

Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2006

Salido Eduardo C, Li Xiao M, Lu Yang, Wang Xia, Santana Alfredo, Roy-Chowdhury Namita, Torres Armando, Shapiro Larry J, Roy-Chowdhury Jayanta

Abstract excerpt

Mutations in the alanine-glyoxylate amino transferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads to renal failure. We generated a null mutant mouse by targeted mutagenesis of the homologous gene, Ag...

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Source

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Identifiers

PMID: 17110443
DOI: 10.1073/pnas.0607218103
PMCID: PMC1838738

Genes

AGXT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17110443-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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