Article
Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer.
Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2006
Salido Eduardo C, Li Xiao M, Lu Yang, Wang Xia, Santana Alfredo, Roy-Chowdhury Namita, Torres Armando, Shapiro Larry J, Roy-Chowdhury Jayanta
Abstract excerpt
Mutations in the alanine-glyoxylate amino transferase gene (AGXT) are responsible for primary hyperoxaluria type I, a rare disease characterized by excessive hepatic oxalate production that leads to renal failure. We generated a null mutant mouse by targeted mutagenesis of the homologous gene, Agxt, in embryonic stem cells. Mutant mice developed normally, and they exhibited hyperoxaluria and crystalluria....
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