Article
Mutations in the hemochromatosis gene and the clinical outcome of multiple sclerosis.
Journal of neuroimmunology - 15 Oct 2008
Ramagopalan Sreeram V, Cukjati Marko, Cernilec Maja, DeLuca Gabriele C, Dyment David A, Degenhardt Alexandra, Sadovnick A Dessa, Serbec Vladka Curin, Ebers George C, Duquette Pierre
Abstract excerpt
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. Given a possible role for dysregulation of iron metabolism in MS disease pathogenesis, we investigated whether or not mutations in the HFE gene influence the prognosis of the disease. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of...
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