Article
No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis.
Journal of neuroimmunology - 1 May 2007
Ramagopalan S V, Deluca G C, Morrison K M, Herrera B M, Dyment D A, Orton S, Bihoreau M T, Degenhardt A, Pugliatti M, Sadovnick A D, Sotgiu S, Ebers G C
Abstract excerpt
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. Apolipoprotein E (APOE) is involved in neuronal remodelling and several studies have attempted to examine the effect of APOE on MS disease severity, but its function in modifying the course of MS is controversial. It has been suggested recently that PVRL2, not APOE, is the...
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