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Article

APOBEC3G-independent reduction in virion infectivity during long-term HIV-1 replication in terminally differentiated macrophages.

Virology - 30 Sept 2008

Miyagi Eri, Schwartzkopff Franziska, Plishka Ronald, Buckler-White Alicia, Clouse Kathleen A, Strebel Klaus

Abstract excerpt

APOBEC3G (APO3G) is a cellular cytidine deaminase with potent antiviral activity. In the case of HIV, the antiviral activity of APO3G is counteracted by the viral Vif protein. Monocyte-derived macrophages (MDM) are terminally differentiated, non-dividing cells susceptible to HIV infection. Human MDM are known to express APO3G and HIV replication in these cells is dependent on Vif. Here we analyzed the correlation...

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Share to gag Gene Products, Human Immunodeficiency Virus

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Source

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Identifiers

PMID: 18675436
DOI: 10.1016/j.virol.2008.06.033
PMCID: PMC2614695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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