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Article

Collapsing SNP genotypes in case-control genome-wide association studies increases the type I error rate and power.

Statistical applications in genetics and molecular biology - 1 Jan 2008

Matthews Abigail G, Haynes Chad, Liu Chang, Ott Jurg

Abstract excerpt

Genome-wide association studies are now widely used tools to identify genes and/or regions which may contribute to the development of various diseases. With case-control data a 2x3 contingency table can be constructed for each SNP to perform genotype-based tests of association. An increasingly common technique to increase the power to detect an association is to collapse each 2x3 table into a table assuming...

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Identifiers

PMID: 18673292
DOI: 10.2202/1544-6115.1325
PMCID: PMC2789285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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