Article
Nonradioactive assay for new microsatellite polymorphisms at the 5' end of the dystrophin gene, and estimation of intragenic recombination.
American journal of human genetics - 1 Aug 1991
Oudet C, Heilig R, Hanauer A, Mandel J L
Abstract excerpt
Indirect tracking of mutation by DNA polymorphisms is still essential for carrier and prenatal diagnosis of Duchenne/Becker muscular dystrophy, at least in the families where no deletion can be detected. Because of the relatively high level of intragenic recombination, informative and easily testable markers at both ends of the gene are necessary for efficient and accurate diagnosis. We report the...
Topics
- Alleles
- Base Sequence
- DNA, Satellite
- Dystrophin
- Female
- Genes
- Genetic Linkage
- Humans
- Introns
- Male
- Molecular Sequence Data
- Muscular Dystrophies