Article
Linkage disequilibria among (CA)n polymorphisms in the human dystrophin gene and their implications in carrier detection and prenatal diagnosis in Duchenne and Becker muscular dystrophies.
Genomics - 1 Jun 1994
Chakraborty R, Zhong Y, de Andrade M, Clemens P R, Fenwick R G, Caskey C T
Abstract excerpt
Four short tandem repeat loci, characterized by length polymorphisms of (CA)n repeats, have been detected within introns 44, 45, 49, and 50 of the human dystrophin gene. The predicted heterozygosities for these loci range from 72 to 93%, and observed allele numbers range from 6 to 19 in 57 normal...
Topics
- Alleles
- Animals
- DNA
- Dystrophin
- Female
- Genetic Carrier Screening
- Hominidae
- Humans
- Introns
- Linkage Disequilibrium
- Mathematics
- Models, Genetic
- Muscular Dystrophies
- Polymerase Chain Reaction
- Polymorphism, Genetic