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Article

Maternal Global Methylation Status and Risk of Congenital Heart Diseases

1 Aug 2008

Abstract excerpt

OBJECTIVE: To investigate whether the association between the maternal methylation status as reflected by low S-adenosylmethionine and high S-adenosylhomocysteine, is detrimental for cardiogenesis and congenital heart disease (CHD) in the offspring. METHODS: As part of a case-control study in the western part of the Netherlands, we evaluated 231 mothers of children with CHD and 315 control mothers of nonmalformed...

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PMID: 18669723
DOI: 10.1097/aog.0b013e31817dd058

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