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Congenital heart defects and biomarkers of methylation in children: a case-control study

27 Sept 2010

Abstract excerpt

BACKGROUND: Derangements in the maternal methylation pathway, expressed by global hypomethylation and hyperhomocysteinemia, are associated with the risk of having a child with a congenital heart defect (CHD). It is not known whether periconception exposure to these metabolic derangements contributes to chromosome segregation and metabolic programming of this pathway in the foetus. DESIGN: In a Dutch...

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PMID: 20868449
DOI: 10.1111/j.1365-2362.2010.02388.x

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