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Article

DNA methylation of the Lamin A/C gene is associated with congenital heart disease.

Birth defects research - 1 Jul 2024

Mukherjee Nandini, Bolin Elijah H, Qasim Amna, Orloff Mohammed S, Lupo Philip J, Nembhard Wendy N

Abstract excerpt

BACKGROUND: Prior studies report associations of maternal serum Lamin A, encoded by the LMNA gene, with fetal congenital heart disease (CHD). It is unknown whether DNA methylation (DNAm) of cytosine-phosphate-guanine (CpG) sites in LMNA impacts the CHD susceptibility. METHODS: We investigated the associations of LMNA DNAm with CHD using publicly available data of CHD cases (n = 197) and controls (n = 134) from...

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Source

Identifiers

PMID: 39073036
DOI: 10.1002/bdr2.2381

Genes

LMNA

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