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Article

GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein

31 Jul 2008

Abstract excerpt

Increased alpha-synuclein gene (SNCA) dosage due to locus multiplication causes autosomal dominant Parkinson's disease (PD). Variation in SNCA expression may be critical in common, genetically complex PD but the underlying regulatory mechanism is unknown. We show that SNCA and the heme metabolism genes ALAS2, FECH, and BLVRB form a block of tightly correlated gene expression in 113 samples of human blood, where...

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PMID: 18669654
DOI: 10.1073/pnas.0802437105

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