Article
Statin myopathy as a metabolic muscle disease.
Expert review of cardiovascular therapy - 1 Aug 2008
Phillips Paul S, Haas Richard H
Abstract excerpt
The etiology of statin myopathy remains unclear and concern about this toxicity is a leading reason that statins are underutilized. A number of observations suggest that this toxicity may be due to the metabolic effects of lipid-lowering in patients with minor muscle disorders. These patients have a high frequency of mutations for metabolic muscle diseases and often have depleted mitochondrial enzymes. Their...
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