Article
CYP56 (Dit2p) in Candida albicans: characterization and investigation of its role in growth and antifungal drug susceptibility.
Antimicrobial agents and chemotherapy - 1 Oct 2008
Melo N R, Moran G P, Warrilow A G S, Dudley E, Smith S N, Sullivan D J, Lamb D C, Kelly D E, Coleman D C, Kelly S L
Abstract excerpt
The complete DNA sequence of Candida albicans DIT2, encoding cytochrome P450 family 56 (CYP56), was obtained, and heterologous expression was achieved in Escherichia coli, where CYP56 was targeted to the membrane fraction. In reconstituted assays with the purified enzyme, CYP56 was shown to catalyze the conversion of N-formyl tyrosine into N,N'-bisformyl dityrosine, a reaction that was dependent on cytochrome...
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