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Article

The D84E variant of the alpha-MSH receptor 1 gene is associated with cutaneous malignant melanoma early onset.

Journal of dermatological science - 1 Dec 2008

F-de-Misa Ricardo, Hernández-Jimenez José Gerardo, Carretero Hernández Gregorio, Pérez-Méndez Lina, Aguirre-Jaime Armando, Flores Carlos, Suárez Hernández José, Perera Molinero Antonio, Claveríe-Martín Félix

Abstract excerpt

BACKGROUND: Alpha-melanocyte-stimulating hormone receptor 1 (MC1R) has an important role in skin pigmentation and variants of the gene have been established as independent risk factors for susceptibility to cutaneous malignant melanoma. OBJECTIVE: To explore whether variants of the gene also influence the onset of the disease. METHODS: We analyzed 285 melanoma patients of European ancestry for common variation in...

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PMID: 18657399
DOI: 10.1016/j.jdermsci.2008.06.001

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