Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A relative weak leg muscle in the rolling Nagoya mouse as a model for Lambert-Eaton myasthenic syndrome.

Journal of neuroimmunology - 15 Sept 2008

Molenaar P C

Abstract excerpt

The Lambert-Eaton myasthenic syndrome (LEMS) is caused by auto-antibodies that affect the activity of presynaptic calcium channels at the neuromuscular junction. Weakness in LEMS is particularly affecting the legs. Here we used leg muscles from the rolling Nagoya (RN) mouse with a R1262G mutation in the alpha-1 subunit of the P/Q-type (Ca(v)2.1) calcium channel. We found that in homozygote flexor digitorum brevis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels, N-Type
Share to Electromyography
Share to Hindlimb

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Inbred Strains

Share to Muscle Contraction

Share to Muscles

Share to Neuromuscular Junction

Share to Nicotinic Antagonists

Source

Identifiers

PMID: 18653245
DOI: 10.1016/j.jneuroim.2008.05.027

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A relative weak leg muscle in the rolling Nagoya mouse as a model for Lambert-Eaton myasthenic syndrome.PMID 18653245Read ↗

An increased expression of Ca(2+) channel alpha(1A) subunit immunoreactivity in deep cerebellar neurons of rolling mouse Nagoya.Semantic proximity Read ↗

Attenuated Ca(2+) release in a mouse model of limb girdle muscular dystrophy 2A.Semantic proximity Read ↗

Neonatal motor functions in Cacna1a-mutant rolling Nagoya mice.Semantic proximity Read ↗

Adenosine A2A receptors activation facilitates neuromuscular transmission in the pre-symptomatic phase of the SOD1(G93A) ALS mice, but not in the symptomatic phase.Semantic proximity Read ↗

Hypermuscular mice with mutation in the myostatin gene display altered calcium signalling.Semantic proximity Read ↗

Inhibition of ubiquitin proteasome system rescues the defective sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA1) protein causing Chianina cattle pseudomyotonia.Semantic proximity Read ↗

Development and use of the incremental twitch subtraction MUNE method in mice.Semantic proximity Read ↗

Change of voltage-gated sodium channel repertoire in skeletal muscle of a MuSK myasthenia gravis mouse modelSemantic proximity Read ↗

Structural study of skeletal muscle fibres in healthy and pseudomyotonia affected cattle.Semantic proximity Read ↗

The contribution of neuromuscular stimulation in elucidating muscle plasticity revisitedSemantic proximity Read ↗

Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor.Semantic proximity Read ↗

Skeletal muscle contraction modulates carbonic anhydrase phenotype in adult mouse dorsal root ganglion neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.