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Article

Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2010

Yu Tao, Clapcote Steven J, Li Zhongyou, Liu Chunhong, Pao Annie, Bechard Allison R, Carattini-Rivera Sandra, Matsui Sei-Ichi, Roder John C, Baldini Antonio, Mobley William C, Bradley Allan, Yu Y Eugene

Abstract excerpt

Copy-number variation in the human genome can be disease-causing or phenotypically neutral. This type of genetic rearrangement associated with human chromosome 21 (Hsa21) underlies partial Monosomy 21 and Trisomy 21. Mental retardation is a major clinical manifestation of partial Monosomy 21. To model this human chromosomal deletion disorder, we have generated novel mouse mutants carrying heterozygous deletions...

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Identifiers

PMID: 20512340
DOI: 10.1007/s00335-010-9262-x
PMCID: PMC3023176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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