Article
G protein subtype specificity of rhodopsin intermediates metarhodopsin Ib and metarhodopsin II.
Photochemistry and photobiology - 1 Jan 2000
Morizumi Takefumi, Kimata Naoki, Terakita Akihisa, Imamoto Yasushi, Yamashita Takahiro, Shichida Yoshinori
Abstract excerpt
Rhodopsin is one of the members of the G protein-coupled receptor family that can catalyze a GDP-GTP exchange reaction on the retinal G protein transducin (Gt) upon photon absorption. There are at least two intermediate states, meta-Ib and meta-II, which exhibit direct interaction with Gt. Meta-Ib binds to GDP-bound Gt, while meta-II forms a complex with Gt having no nucleotide, suggesting that meta-Ib is a state...
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