Article

Neuronal mechanism of a BK channelopathy in absence epilepsy and movement disorders

2021-07-01

Abstract excerpt

A growing number of gain-of-function (GOF) BK channelopathy have been identified in patients with epilepsy and paroxysmal movement disorders. Nevertheless, the underlying pathophysiology and corresponding therapeutics remain obscure. Here we utilized a knock-in mouse model carrying human BK-D434G channelopathy to investigate the neuronal mechanism of BK GOF in the pathogenesis of epilepsy and movement disorders. W...

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Literature Corpus work: 3d6de892-5d6f-5bfd-9ad1-c4ad732312b1
DOI: 10.1101/2021.06.30.450615

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