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Article

Genotype-phenotype associations between chymase and angiotensin-converting enzyme gene polymorphisms in chronic systolic heart failure patients.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Aug 2008

Amir Ruthie E, Amir Offer, Paz Hagar, Sagiv Moran, Mor Roi, Sagiv Michael, Lewis Basil S

Abstract excerpt

PURPOSE: Angiotensin II, which plays a crucial role in the myocardial remodeling process of heart failure, is generated via the angiotensin-converting enzyme and chymase pathways. We studied angiotensin-converting enzyme and chymase-1 polymorphisms in patients with systolic heart failure and the correlation with clinical status and left ventricular function. METHODS: We genotyped 195 patients with heart failure...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18641516
DOI: 10.1097/gim.0b013e3181804b9c

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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