Article
[Pharmacogenetics of chronic heart failure--beta blockers].
Casopis lekaru ceskych - 1 Jan 2006
Vasků A, Spinarová L, Pávková-Goldbergová M, Spinar J, Soucek M, Vítovec J
Abstract excerpt
BACKGROUND: Activation of the renin-angiotensin (RAS) cascade and sympathetic nervous systems adversely affect heart failure progression. ACE deletion allele (ACE D) of insertion/deletion polymorphism in the gene coding for angiotensin-1 converting enzyme is associated with increased renin-angiotensin activation. The aim of the study was to test pharmacogenetic associations of I/D ACE genotype with beta blockers...
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