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Article

Mutational characterization of pancreatitis-associated protein 2 domains involved in mediating cytokine secretion in macrophages and the NF-kappaB pathway.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008

Viterbo Domenico, Bluth Martin H, Mueller Cathy M, Zenilman Michael E

Abstract excerpt

Pancreatitis-associated protein 2 (PAP2) is a member of the Reg3 gene family and is classified as a group 7 C-type lectin-like protein. In rats, each of the three PAP isoforms has independent immunologic functional effects on macrophages. We have previously shown that PAP2 up-regulates inflammatory cytokines in macrophages in a dose-dependent manner and acts through NF-kappaB mechanisms. In this study, we aimed...

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PMID: 18641333
DOI: 10.4049/jimmunol.181.3.1959

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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