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Article

Reg3β Deficiency Impairs Pancreatic Tumor Growth by Skewing Macrophage Polarization

19 Jul 2013

Abstract excerpt

The lectin Reg3β provides crucial protection to various tissues against inflammation, a potential risk factor for pancreatic ductal adenocarcinoma. Reg3β is also overexpressed in serum and pancreatic juice from patients with this cancer, but its function in this context remains to be elucidated. In this study, we investigated the role of Reg3β in tumor development in an orthotopic mouse model of pancreatic...

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PMID: 23867474
DOI: 10.1158/0008-5472.can-12-3057

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