Article
Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection.
BMC evolutionary biology - 17 Jul 2008
Ojosnegros Samuel, Agudo Rubén, Sierra Macarena, Briones Carlos, Sierra Saleta, González-López Claudia, Domingo Esteban, Cristina Juan
Abstract excerpt
BACKGROUND: The molecular events and evolutionary forces underlying lethal mutagenesis of virus (or virus extinction through an excess of mutations) are not well understood. Here we apply for the first time phylogenetic methods and Partition Analysis of Quasispecies (PAQ) to monitor genetic distances and intra-population structures of mutant spectra of foot-and-mouth disease virus (FMDV) quasispecies subjected to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.