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Article

TNF promoter polymorphisms associated with muscle phenotypes in humans.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Sept 2008

Liu Dongmei, Metter E Jeffrey, Ferrucci Luigi, Roth Stephen M

Abstract excerpt

Tumor necrosis factor-alpha (TNF-alpha) is a potent catabolic factor to skeletal muscle. Single-nucleotide polymorphisms (SNPs) in the promoter region of the TNF-alpha coding gene, TNF, have been implicated in the interindividual variation in TNF-alpha production via transcriptional regulation. The present study investigated the association of muscle phenotypes with five TNF promoter SNPs, which potentially have...

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Identifiers

PMID: 18635873
DOI: 10.1152/japplphysiol.90655.2008
PMCID: PMC2536817

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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