Article
Reconstruction of cell lineage trees in mice.
PloS one - 9 Apr 2008
Wasserstrom Adam, Adar Rivka, Shefer Gabi, Frumkin Dan, Itzkovitz Shalev, Stern Tomer, Shur Irena, Zangi Lior, Kaplan Shai, Harmelin Alon, Reisner Yair, Benayahu Dafna, Tzahor Eldad, Segal Eran, Shapiro Ehud
Abstract excerpt
The cell lineage tree of a multicellular organism represents its history of cell divisions from the very first cell, the zygote. A new method for high-resolution reconstruction of parts of such cell lineage trees was recently developed based on phylogenetic analysis of somatic mutations accumulated during normal development of an organism. In this study we apply this method in mice to reconstruct the lineage...
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