Article
[Impact of HSP90 Inhibition on Viability and Cell Cycle in Relation to p53 Status].
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti - 1 Jan 2000
Pastorek M, Müller P, Vojtěšek B
Abstract excerpt
BACKGROUND: Chaperone system inhibition is a recent promising strategy for cancer treatment that exploits increased metabolic needs required for rapid proliferation as well as higher level of proteotoxic stress in neoplastic cells. Chaperone HSP90 plays a key role in proper folding of many de novo synthesized proteins, so-called clients, including tumor suppressor p53 which is commonly mutated in majority of...
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