Article
Role for primary cilia in the regulation of mouse ovarian function.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2008
Johnson Ellen T, Nicola Teodora, Roarty Kevin, Yoder Bradley K, Haycraft Courtney J, Serra Rosa
Abstract excerpt
Ift88 is a component of the intraflagellar transport complex required for formation and maintenance of cilia. Disruption of Ift88 results in depletion of cilia. The goal of the current study was to determine the role of primary cilia in ovarian function. Deletion of Ift88 in ovary using Cre-Lox recombination in mice resulted in a severe delay in mammary gland development including lack of terminal end bud...
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